Neoplastic state

Takahashi M, Baeeett C and Tsutsui T (2002) Transformation by inorganic arsenic compounds of normal Syrian hamster embryo cells into a neoplastic state in which they become anchorage-independent and cause tumors in newborn hamsters. Int J Cancer 99 629-634. 

The type and location of the neoplastic lesion (as stated on the patient s chart)... 

EN is indicated for the patient who cannot or will not eat enough to meet nutritional requirements and who has a functioning GI tract. Additionally, a method of enteral access must be possible. Potential indications include neoplastic disease, organ failure, hypermetabolic states, GI disease, and neurologic impairment. 

We hypothesize that different patterns of nuclear p-catenin occur, depending on the localization of neoplastic cells in the tumor and correlating with variations in the differentiation state of malignant hepatocyte subpopulations. At the inner area of the cancerous tissue, neoplastic hepatocytes might have low or are even devoid of nuclear p-catenin and exhibit proliferation. In contrast, malignant hepatocytes that have undergone EMT at the invasive front might... 

From studies in colon cancer, it seems that cells progressing from the normal to the tumor state accumulate mutations. That is, a neoplastic phenotype is acquired. 

In a two-year study (United States National Toxicology Program, 1989 Kari et al., 1992), dose-dependent hepatic morphological changes (anisokaryosis, elevated frequency of multinucleated cells) were observed in male mice. In a long-term feeding study (0.8% in the diet) (Shibata et al., 1991), hepatic centrilobular hypertrophy was observed in males and forestomach hyperplasia in both males and females, while no non-neoplastic changes in the kidney were reported. 

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