Neohesperidin dihydrochalcone NHDC

Citrosa 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinna-moyl)phenyl-2-0-(6-deoxy-a-L-mannopyranosyl)-P-D-gluco-pyranoside 3,5-dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl) propionyl]phenyl-2-0-(6-deoxy-a-L-mannopyranosyl)-P-D-glucopyranoside E959 neohesperidin DC neohesperidin DHC neohesperidine dihydrochalcone NHDC 1-propanone, l-[4-[[2-0-6-deoxy-a-L-mannopyranosyl)-P-D-glycopyranosyl ]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl) Sukor. 

Figure 2 Analytical methodologies for the determination of high-intensity sweeteners. NHDC, neohesperidine dihydrochalcone LC, liquid chromatography GC, gas chromatography TLC, thin-layer chromatography CE, capillary electrophoresis SP, spectropho-tometric EA, electroanalytical T, titrimetry G, gravimetry 1C, immunochemical. Source of information Chemical Abstracts (until January 2004).

Other groups of flavonoids are chalcones, intermediates in the biosynthesis of all other flavonoids, as well as dihydrochalcones, aurones, or dihydroflavonols, together with biflavonoids, which are flavonoid dimers different from proanthocyanidins, since they are based on flavones and flavanones linked through a carbon-carbon bond or less frequently by an ether bond. " In general, all these flavonoids are less abundant in foods than the compounds mentioned above, although in some cases they may have important applications in the food industry as for the sweetener neohesperidin dfliydrochalcone (NHDC). 

Many other dihydrochalcones have been made, but most of the toxicological studies have been conducted using NHDC and thus (20) has been petitioned and allowed for use. Neohesperidin is best isolated from the bitter orange (Seville orange), but it can also be synthesized from (18) and isovanillin [621-59-0] (21) (Fig. 7) (98). 

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