Seville oranges

Many other dihydrochalcones have been made, but most of the toxicological studies have been conducted using NHDC and thus (20) has been petitioned and allowed for use. Neohesperidin is best isolated from the bitter orange (Seville orange), but it can also be synthesized from (18) and isovanillin [621-59-0] (21) (Fig. 7) (98). 

EDWARDS D J, FITZSIMMONS M E, SCHUETZ E G, YASUDA K, DUCHARME M P, WARBASSE L H, WOSTER p M, SCHUETZ J D, WATKINS p (1999) 6, 7 -Dihydroxybergamottm in grapefruit juice and Seville orange juice effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther. 65 237-44. 

Orange, Seville Orange, Valencia Passion fruit Peach Pear... 

In addition to GFJ, interactions with certain medications also have been shown for Seville orange juice, although Seville oranges are usually not processed to juice (27,28). 

Penzak SR, Acosta EP, Turner M, et al. Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics. J Clin Pharmacol 2002 42(10) 1165-1170. 

Di Marco MP, Edwards DJ, Wainer IW, Ducharme MP. The effect of grapefruit juice and Seville orange juice on the pharmacokinetics of dextromethorphan the role of gut CYP3A and P-glycoprotein. Life Sci 2002 71(10) 1149-1160. 

Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice-felodipine interaction comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther 2001 69(l) 14-23. 

Orange Oil, Bitter, Coldpressed, occurs as a pale yellow or yellow-brown liquid with the characteristic aromatic odor of the Seville orange and an aromatic, somewhat bitter taste. It is the volatile oil obtained by expression, without the use of heat, from the fresh peel of the fruit of Citrus aurantium L. (Fam. Rutaceae). It is miscible with absolute alcohol and with an equal volume of glacial acetic acid. It is soluble in fixed... 

CALCIUM CHANNEL BLOCKERS GRAPEFRUIT JUICE t bioavailability of felodipine and nisoldipine (with reports of adverse effects), and t bioavailability of isradipine, lacidipine, lercanidipine, nicardipine, nifedipine, nimodipine and verapamil (without reported adverse clinical effects) Postulated that flavonoids in grapefruit juice (and possibly Seville oranges and limes) inhibit intestinal (but not hepatic) CYP3A4. They also inhibit intestinal P-gp, which may t the bioavailability of verapamil Avoid concurrent use of felodipine and nisoldipine and grapefruit juice... 

Malhotra S, Fitzsimmons ME, Bailey DG, Watkins PB. Use of Seville orange juice to knock out intestinal CYP3A4. Paper presented at the annual meeting of the American Association of Pharmaceutical Scientists (abstract 2091), New Orleans, LA, November 1999. 

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