Nauclea latifolia

It is interesting to note that the presence of a dihydropyridine unit, analogous to the one observed in lyaline (10) and lyadine (11), has also been identified in nauclefoline (14), an alkaloid isolated from the leaves of Nauclea latifolia (21). On the other hand, the structural analogy between the angustine bases (15) and... 

The leaves of Nauclea latifolia contain naufoline, angustine, cadambine, 3a-dihydrocadambine, and a new alkaloid, naulafine, which has been formulated,57 on spectroscopic evidence, as (81). Another new alkaloid is strychno-rubigine (10-methoxyisositsirikine), which occurs in the root bark of Strychnos rubiginosa DC.58 Antirhine and pleiocarpamine have been found in the leaves and stem bark of Alstonia odontophora Boiteau [A. roeperi van Heurck et Mull.-Arg.],59 and pleiocarpamine, pleiocarpamine N-oxide, geissoschizine,... 

Nauclea latifolia. la Isodolichantoside and 16-ep/-diploceline are new epimers of known bases which have been reported416 to occur in the root bark of Strychnos gossweileri. 

Nauclea latifolia Rubiaceae Antihypertensive, antimicrobial Fever, stomachache, diarihea Alkaloids. 10, 17, 19... 

F.V.M., from the leaves, stems, and flowers of U. guaianensis (Aubl.) Gmel., from Strychnos camptoneura, and from the root bark of Nauclea latifolia Sm. Angustoline, and very probably (t.l.c. evidence) angustidine also, occur in U. rhynchophylla and U. homomallaand angustoline occurs in N. latifolia. Preliminary t.l.c. evidence was also obtained for the presence of angustine-type alkaloids in a number of other African and Asian Strychnos species. "... 

Polar compounds appear to be the active constituents of Nauclea latifolia [58]. S. decussata contains the only glucoindole alkaloid isolated from Strychnos of Madagascar [12], together with trinitrogenated alkaloids. It is possible that similar glucoindole alkaloids may be present in other Strychnos species of Madagascar and may be responsible for their reported antimalarial activity. These hydrophilic compounds... 

Rewarding sources of monoterpene alkaloid glycosides have been the Asiatic tree Adina rubescens Hemsl. and related Rubiaceous plants A. cordifolia (Roxb.) Hook. f. ex Brandis (1, 2), Nauclea latifolia Sm. (3), N. diderrichii Merrill (4), and Anthocephalus cadamba Miq. (5). The heart-wood and bark of the first has yielded so far no less than nine glycoalkaloids... 

Donalisio M, Nana HM, Ngane RAN, Gatsing D, Tchinda AT, Rovito R, et al. In vitro anti-Herpes simplex viras activity of crude extract of the roots of Nauclea latifolia smith (Rubiaceae). BMC Complement Altern Med 2013 13 266. 

Deeni Y, Hussain H (1991) Screening for antimicrobial activity and for alkaloids of Nauclea latifolia. J Ethnopharmacol 35 91-96. doi 10.1016/0378-8741(91)90137-3 Cardoso CL, Castro-Gamboa I, Silva DHS, Furlan M, Epifanio RA, Pinto AC, Rezende CM, Lima JA, Bolzani VS (2004) Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors. J Nat Prod 67 1882-1885. doi 10.1021/np049863m... 

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