Nature structural conservatism

Figure 4. Nature s conservatism and diversity found in a protein structure similarity cluster. The conservatism found in the cluster can be used for the selection of pre-validated guiding structures for compound library design. The chemical diversity of the compound library is needed to address the biological diversity found in the binding sites of the cluster members.

Implications for Library Design Nature s Structural Conservatism and Diversity 379... 

As has been mentioned earlier, the overall disposition of proteins is not altered whenever differing objectives are addressed. Drawing to both this structural conservatism and the consistency of the operative sequence, and connecting to the involvement of minimal surfaces in enzymatic processes, it seems only natural to try to identify geometrical influences among other protein-mediated transactions. 

FIGURE 9.13 Structural conservatism and diversity in proteins and their natural Ugands. 

FIGURE 9.13 Structural conservatism mid diversity in proteins mid their natural ligmids. 

For example, E. G. Mazurs (note 2, p. 105) expresses the discord as follows The periodicity of atomic structure must be accepted as a Natural Law. Therefore, scientists have to change their minds, get away from the conservatism that accepts only Mendeleev s chemical table as right, and adjust the other phenomena to this phenomenon that is, derive the chemical and physical properties of the elements from the electronic structure of the atoms. ... 

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