Natural extracellular matrix microenvironment

Li et al. evaluated the potential of nanofiber matrices of polymer mimicking the real microenvironment of extracellular matrix for cell growth. The study revealed that nanofiber matrices favor better support cell attachment and cell viability compared to soHd-walled matrices. Three-dimensional structures showed similarity to the extracellular matrices component coUagen. These nanomatrices combined the advantages of biodegradation, mechanical strength, and nanostrucmre of natural extracellular matrix, which leads to better cell compatibility thereby indicating its application as fiimre implant biomaterial development. 

In its natural environment, hematopoiesis resides in a well-defined microenvironment characterized by local geometry (structure and vasculature), by stromal cells (accessory cells of mixed origin), and by an extracellular matrix composed of coUagen-like molecules and proteoglycans, produced by stromal cells (Nielsen, 1999). Thus, it is bkely that hematopoietic stem and progenitor cells (HSPCs) are influenced by accessory cells and the microenvironment they create in several ways. 

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