National Research Council Toxicity Testing reports

An attempt to structure these activities was presented in 2012 [5] by proposing the approach as given in Fig. 1. These activities fit very well in the new approaches proposed for future strategies in toxicity testing as, e.g., proposed in the reports by the Dutch Health Council [1] and the US National Research Council [2], Steps forward on the proposed approaches were presented for a number of areas for which in vitro approaches were not available yet [54],... 

Another level of enhanced effort will be in the area of epidemiology, both traditional and molecular, and human in vitro research in support of the identification of key events in humans and of the human relevance of an animal MoA. The recently published National Research Council (NRC) Report, Toxicity Testing in the 21st Century A Vision and a Strategy (NRC 2007), provides a set of research options for enhancing the use of in vitro test systems with an emphasis on human cells. This... 

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