National Cholesterol Education Program Adult Treatment Panel

Grundy SM, Cleeman JT, Merz CN et al (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110 227-239... 

Statins (and National Cholesterol Education Program Adult Treatment Panel III diet)... 

The National Cholesterol Education Program Adult Treatment Panel III guidelines have set the optimal level for low-density lipoprotein (LDL) cholesterol for all adults as less than 100 mg/dL (2.59 mmol/L). 

Insulin resistance has been associated with a number of other cardiovascular risks, including abdominal obesity, hypertension, dyslipidemia, hypercoagulation, and hyperinsulinemia. The clustering of these risk factors has been termed metabolic syndrome. It is estimated that 50% of the United States population older than 60 years of age have metabolic syndrome. The most widely used criteria to define metabolic syndrome were established by the National Cholesterol Education Program Adult Treatment Panel III Guidelines (summarized in Table 40-2). 

The National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) recommends that a fasting lipoprotein profile and risk factor assessment be used in the initial classification of adults. 

Stone NJ, Bilek S, Rosenbaum S. Recent National Cholesterol Education Program Adult Treatment Panel III update adjustments and options. Am J Cardiol. 2005 96(4A) 53E-59E. 

Feldman T, Koren M, Insull W, et al. Treatment of high-risk patients with ezetimibe plus simvastatin co-administration versus simvastatin alone to attain National Cholesterol Education Program Adult Treatment Panel III low-density lipoprotein cholesterol goals. Am.J. Cardiol, 2004, 93, 1481-1486. 

Sempos, C.T. Cleeman, J.I. Carroll, M.D. Johnson, C.L. Bachorik, P.S. Gordon, D.J. Burt, V.L. Briefel, R.R. Brown, C.D. Lippel, K. Rifkind, B.M. Prevalence of high blood cholesterol among U.S. adults An update based on guidelines from the second report of the National Cholesterol Education Program adult treatment panel. JAMA, J. Am. Med. Assoc. 1993, 269 (23), 3009-3014. 

S. M. Grundy, J. I. Cleeman, C. N. Merz, H. B. Brewer, Jr., L. T. Clark, D. B. Hunninghake, R. C. Pasternak, S. C. Smith, Jr., and N. J. Stone, Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Arterioscler Thromb Vase Biol 24 el49-el61 (2004). 

Sempos, C.T. et al. (1993). Prevalence of high blood cholesterol among U.S. adults. An update based on guidelines from the second Report of the National Cholesterol Education Program Adult Treatment Panel, JAMA, 269, 3009. 

---