National Cancer Institute System

Structure and Nomenclature Search System. This system links the collection of chemical databases found in the Chemical Information System (CIS), one of the first interactive systems for stmcture and substmcture searching. References from the separate files can be retrieved by SANSS using CAS Registry Numbers, and the database of stmctures may be searched for stmctures or substmctures. An adaptation of the SANSS software for substmcture searching has been incorporated in the Dmg Information System of the National Cancer Institute for its own use (54). 

HSDB = Hazardous Substance Data Bank NCI = National Cancer Institute NIOSH = National Institute for Oooupational Safety and Health OHM/TADS = Oil and Hazardous Materials/Teohnical Assistance Data System RTECS = Registry of Toxio Effects of Chemioal Substances... 

In a study reported by the National Cancer Institute (NCI 1980), rats exposed to 16-1,694 mg/kg/day (100-10,000 mg/L) and mice exposed to 25-2,642 mg/kg/day (100-10,000 mg/L) phenol in drinking water exhibited no indication of histopathological effects on the respiratory system after 13 weeks of exposure. No histological abnormalities of the respiratory tract were observed in rats or mice exposed to 2,500 or 5,000 ppm phenol in drinking water for 103 weeks (mg/kg/day doses 322 or 645 for male rats 360 or 721 for female rats 590 or 1,180 for male mice 602 or 1,204 for female mice) (NCI 1980). 

CAS = Chemical Abstracts Service DOT/UN/NA/IMCO - Department of Transportation/United Nations/North America/International Maritime Dangerous Goods Code EPA - Environmental Protection Agency HSDB -> Hazardous Substances Data Bank NCI - National Cancer Institute NIOSH National Institute for Occupational Safety and Health OHM/TADS - Oil and Hazardous Materials/Technical Assistance Data System RTECS - Registry of Toxic Effects of Chemical Substances... 

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