National Cancer Institute’s 60

Pharmacogenomics of the National Cancer Institute s 60-Tumor Cell Panel... 

Much of the current work on tylophorine alkloids was prompted by their profound antitumor activity. Evaluation of tylophorine (1) and related analogs in the National Cancer Institute s antitumor screen showed a uniform and potent growth inhibitory effect (average GT50 = 10 M) against all 60 cell lines, with notable selectivity toward several refractory cell lines, including melanoma and lung tumor cell lines [77]. 

Hu K, Yao X (2001) Methyl Protogracillin (NSC-698792) The Spectrum of Cytotoxicity Against 60 Human Cancer Cell Lines in the National Cancer Institute s Anticancer Drug Screen Panel. Anticancer Drugs 12 541... 

Cephalostatin 1 (119) is among the most powerful anticancer agents ever tested, displaying subnanomolar-to-picomolar cytotoxicity against much of the National Cancer Institute s (NCI) 60-cell line panel, with femtomolar activity against the P388 cell line and in the Purdue Cell Culture Laboratory (PCCL) human tumor panel [109,110]. 

Posner and coworkers have prepared a series of semi-synthetic and synthetic ether and ester-linked dimers that were found to have potent anti-proliferative and antitumour activities in vitro. Some of these trioxane dimers were found to be as antiproliferative as calcitriol, the hormonally active form of vitamin D, which is used to treat psoriasis, a skin disorder characterized by uncontrolled cell prohferation. Of the semi synthetic dimers, a polyethylene glycol-linked dimer 107, with S-stereochemistry at both of the lactol acetal positions, was found to be very anti-proliferative and showed activity against leukaemia and colon cancer cell hues in the National Cancer Institute (NCI), USA 60-cell line assay. 

NATIONAL CANCER INSTITUTE (NCI) S 60-CELL SCREENING AND GENE EXPRESSION DATA... 

As part of their efforts to identify clinically useful antitumor compounds, the U. S. National Cancer Institute (NCI) in 1989 established a panel of 60 human tumor cell lines representing seven major categories of human cancer. They have foimd that the activity profile for various compounds is sufficiently characteristic to be employed as a means of identification, using specialized pattern-recognition algorithms. 

U.S. Department of Health, Education, and Welfare, Bloassay of Captan for Possible Carcinogenicity", National Cancer Institute, Rethesda, Md.,... 

In order to find effective natural products with anticancer activity, the national cancer institute of USA evaluated numerous plant extracts from thousands of plant species as well as other natural source [12]. These efforts led to find several anticancer drug s which are commercially available and approved by the FDA. According to statistics more than 60 % of anticancer drugs are of natural origin [13]. 

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