Naproxen 358 INDEX

There are small changes in serum albumin concentration with age, with concomitant small effects on protein binding of some highly bound drugs such as naproxen, salicylate, and warfarin. For such drugs the free concentration rather than the total plasma concentration is a better predictor of drug dose requirements, particularly for drugs with low therapeutic index (difference between the therapeutic... 

Naproxen is a propionic acid derivative that has a structure similar to ibuprofen and ketoprofen. It can be administered either i.v. or p.o. to horses, even though it is poorly absorbed with a bioavailability of approximately 50% (Pasargiklian Bianco 1986). It has a relatively short half-life in plasma (4h) (Tobin 1979). There is little information available on the therapeutic index of naproxen in the horse. 

The standard compounds will all be available as solutions of 1 g of each dissolved in 20 mL of a 50 50 mixture of methylene chloride and ethanol. The purpose of the first reference plate is to determine the order of elution (R values) of the known substances and to index the standard reference mixture. Several of the substances have similar Revalues, but you will note a different behavior for each spot with the visualization methods. On the sample plate, the standard reference mixture will be spotted, along with Naproxen sodium and several solutions that you will prepare from commercial analgesic tablets. These tablets will each be crushed and dissolved in a 50 50 methylene chloride-ethanol mixture for spotting. 

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