Naproxen displacement

Tiagabine is displaced from protein by naproxen, salicylates, and valproate. 

It is oxidized hy CYP3A4 enzymes, and other drugs may alter its clearance. Tiagahine is displaced from protein hy naproxen, salicylates, and valproate. The minimal effective adult dose level is considered to be 30 mg/day. 

The effects of aspirin on gastrointestinal mucosa will lead to additive effects if it is used concurrently with other drugs that have an irritant effect on the stomach, notably other NSAIDs or glucocorticoids (105,106). Salicylates can be displaced from binding sites by some NSAIDs such as naproxen, or in turn displace others such as piroxicam. 

Naproxen Valproate Interaction of little or no clinical significance Displacement from plasma protein binding sites... 

Oral anticoagulants + naproxen Increased anticoagulant effect and risk of Gl bleeding Naproxen has ulcerogenic potential. Displacement from protein Best to avoid concurrent administration. Monitor patient... 

Drug Interactions. Enzyme inducers, such as carbamazepine and phenytoin, increase tiagabine clearance and decrease the half-life. Food decreases the rate but not the extent of absorption. Tiagabine is displaced from protein by naproxen, salicylates, and valproate. However, tiagabine does not displace phenytoin, valproic acid, amitrypty-line, tolbutamide, or warfarin. ... 

A study in 6 healthy subjects found that naproxen 500 mg twice daily moderately decreased the AUC of a single 800-mg dose of sodium valproate by 11%. Similarly, in another study, when naproxen 500 mg twice daily was given with sodium valproate 500 mg twice daily the AUC of valproate was decreased by 20% and the AUC of naproxen was increased by 7%. It is suggested that naproxen and sodium valproate displace each other from their protein binding sites. The clinical relevance of these modest changes is uncertain, but is likely to be small. ... 

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