Ulcerogenic potential

The secretory potential of a candidate compound might be much more problematic under safety aspects due to its ulcerogenic potential compared to the antisecretory potential of a candidate compound with a different primary indication. 

The Shay-rat has been proven to be a valuable tool to evaluate the ulcerogenic or anti-ulcerogenic potential of a candidate compound independent of its mechanisms of action. However, due to the prolonged distress to the animals the use of this method should be ethically balanced very carefully against the expected added value of the study outcome. 

Oral anticoagulants + naproxen Increased anticoagulant effect and risk of Gl bleeding Naproxen has ulcerogenic potential. Displacement from protein Best to avoid concurrent administration. Monitor patient... 

The well-known ulcerogenic potential of potassium chloride tablets has not been eradicated by the introduction of slow-re-lease forms. A case of oesophageal obstruction and ulceration with such a preparation was reported in SED VIll (p. 1073) in that... 

Szabo S, Silver EH, Gallagher GT, et al. 1983. Potentiation of duodenal ulcerogenic action of acrylonitrile by PCB or phenobarbital in the rat. Toxicol Appl Pharmacol 71 451-454. 

The barrier formed at the ulcer site protects the ulcer from the potential ulcerogenic properties of pepsin, acid, and bile, thus allowing the ulcer to heal. Pharmacokinetics Sucralfate is minimally absorbed from the Gl tract following an oral dose. The duration of action depends on the time that the drug is in contact with this site. Binding to the ulcer site has been shown for up to 6 hours. Approximately 95% of the dose remains in the Gl tract. 

The specific risks of salt and water retention in cardiac and renal disease have already been mentioned. The potential for ulcerogenic activity should be kept in mind if phenylbutazone is given to a patient with a history of peptic ulceration. Patients who are hypersensitive to other drugs (especially aspirin) should be carefully monitored when taking phenylbutazone. 

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