2- Naphthylamine tobacco

Mineral oils (untreated and mildly treated) -Coal-tar pitches -Tobacco smoke 2-Naphthylamine Benzidine 4-Aminobiphenyl Asbestos... 

Chromium(VI] compounds -Solar radiation Nickel compounds Radon and its decay products -Mustard gas (Sulfur mustard) -N -Bis(2-chloroethyl)-2-naphthylamine Analgesic mixtures containing phenacetin -Diethylstilbestrol Estrogens, nonsteroidal Betel quid with tobacco Arsenic and arsenic compounds Azathioprine... 

Also included in Table XXIII-5 are several components that do not appear in any of the Hoffmann co-authored lists but recently have been included with analyses of Hoffmann-listed components, for example, 1-naphthalenamine (1-amino-naphthalene a-naphthylamine), 3-aminobiphenyl ([l,T-bip-henyl]-3-amine), propionaldehyde (propanal), butyraldehyde (butanal), and acetone (2-propanone). Table XXIII-5 includes several tobacco smoke components that the lARC has reclassified with regard to their tumorigenicity, for example, chrysene and di(2-ethylhexyl) phthalate. Thus, chrysene no longer appears on the more recent Hoffmann lists (1740, 1741, 1743, 1744) and di(2-ethylhexyl) phthalate was omitted from (1743,1744). 

Masuda, Y, D. Hoffmann and E.L. Wynder CX-Naphthylamine and P-naphthylamine in cigarette smoke 22nd Tobacco Chemists Research Conference,... 

P-naphthylamine from cigarette smoke 21st Tobacco... 

Despite the results from the climbing boys study, the list of known chemical carcinogens grew slowly. Prior to 1950, only three chemical mixmres were known to cause cancer in humans coal soot, tobacco, and naphthylamines from the production of synthetic dyes. Tobacco, like coal tar, had been recognized as a carcinogen ever since another London physician working in the 1700s, Dr. John Hill, first observed that excessive use of smokeless tobacco, or snuff, led to nasal cancer. 

Unlike coal tar and tobacco, the link between naphthylamines and carcinogenicity was not discovered until the 1870s. Prior to that time, aU industrial dyes were derived from namral sources. However, with the advent of synthetic fuchsine dyes in Germany came reported cases of bladder cancer. When World War I interrupted the industrial cooperation between Germany and the United States, an American... 

The Delaney Clause generated criticism almost immediately, as it brought a non-quantitative standard to a quantitative issue. At the time of the clause s adoption, only four substances were known to be carcinogenic soot, radiation, tobacco smoke, and p-naphthylamine. Two developments occurred over the next twenty years that brought the problem with the Delaney Clause to the forefront. The first was a dramatic increase in food safety testing. To make a quantitative decision regarding the potential carcinogenicity... 

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