Naphthyl thioether

Most 1-methyl-l-benzothiepiniiun salts (42) are thermally more stable than the corresponding benzothiepines (Table 13). Thermolysis of the salts gave naphthyl thioethers (79) (Equation (6)) <77TL1985, 83LA425,90ZN(B)1573>. 

Enantiomer separation of various compounds such as barbituric acids, benzoin, MTH-proline, glutethimide, a-methyl-oc-phenyl-succinimide, y-phenyl-y-butyrolac-tone, methyl-mandelate, l-(2-naphthyl)ethanol, mecoprop methyl, diclofop methyl and fenoxaprop methyl by pressure supported CEC on a permethyl-P-cyclodextrin modified stationary phase was described by Wistuba and Schurig [42-44]. Three different separation beds were used (i) permethyl-P-cyclodextrin was covalently attached via a thioether to silica (Chira-Dex-silica) [42], permethyl-P-cyclodextrin was linked to a dimethylpolysiloxane and thermally immobilized (ii) on silica (Chirasil-Dex-silica) [43] or (iii) on a silica monolith (Chirasil-Dex-monolith) [44], respectively. 

No Name Boiling point, C S-Mkyl thturonium picrate 1 Naph thyl amide Anilide Alkyl mercunc halide Picratc of 2-naphthyl ether 2,4-l>nttro phenyl thioether 2,4-Dinitro- phenyl sulfone... 

In a number of cases aromatic thioethers can be used for the stabilization of polyolefins however, in most cases their stabilizing effectiveness is low. Of llie best investigated compounds, diphenyl sulfide, phenyl-benzyl sulfide, di-/3-naphthyl sulfide, methyl-/ -naphthyl sulfide [41], sulfides of the thiophene series [28], etc., are known. In most cases amino- or phenol sulfides such as 2,2 -thio-bis-(4-methyl-6-tert-butyl-phenol), thio-bis-/3-naphthol, thio-bis-(N-phenyl-2-naphthylamine) [41], etc., are used. 

As in the case of compounds XIII and LII, the carboxyhc acid function in the thioether analog of clofibrate has been exchanged for the tetrazole moiety to afford the hypocholesterolemic compound CVII [282]. Substituted naphthyl-oxyisobutyric acids (see compound CVIII) have also been reported to possess hypocholesterolemic activity [283]. 

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