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A series of monomeric and dimeric naphthoquinones with potential for treatment of Leishmania infections were identified in vitro using a direct cytotoxicity assay against extracellular promastigotes of Leishmania spp. [196,197]. Lapachol was evaluated in vitro against intracellular amastigotes of Leishmania braziliensis and then tested in an animal model (hamster) to try to reproduce the leishmanicidal activity. In vitro lapachol exhibited an... [Pg.330]

See other pages where Naphthoquinones, leishmanicidal is mentioned: [Pg.749] [Pg.749]