1-Naphthol ethyl salicylate

Problem 19.3 Write structural formulas for (a) p-cresol, (b) 2-nitro-4-bromophenol, (c) 4- -hexylresorcinol, (d) ethyl salicylate, (e) /3-naphthol. 

Nencki introduced salol in 1886 and. so pre.sented to the science of therapy the "salol principle." In salol. two toxic sub.stances (phenol and salicylic acid) were combined into an e.ster that taken internally slowly hydroly/es in the intestine to give the antiseptic action of its components. This type of ester is referred to as a full. salol or true salol when toth components of the ester are active compounds. Examples are guaiacol benzoate. /3-naphthol benzoate, and salol. The salol principle can be applied to esters in which only the alcohol or the acid is the toxic, active or corrosive portion this type is called a partial salol. Examples of partial sulols that contain an active acid arc ethyl salicylate and methyl salicylate. Examples of partial sulols that contain an active phenol are creosote carbonate, thymol carbonate, and guaiacol carbonate. Althtxigh many. salol-typc compounds have been prepared and used tu. some extent, none is presently... 

Benzo[b]xanthone formation in 74% yield occurred readily in the reaction of ethyl salicylate and 1-naphthol at elevated temperature in refluxing diphenyl ether during 8 hours (ref.93). 

Benzyl phenyl acetate Benzyl phenyl ethyl ether Benzyl priopionate Benzyl salicylate Bensylidine acetone Beta naphthol isobutyl ether... 

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