Partial salols

Nencki introduced salol in 1886 and. so pre.sented to the science of therapy the "salol principle." In salol. two toxic sub.stances (phenol and salicylic acid) were combined into an e.ster that taken internally slowly hydroly/es in the intestine to give the antiseptic action of its components. This type of ester is referred to as a full. salol or true salol when toth components of the ester are active compounds. Examples are guaiacol benzoate. /3-naphthol benzoate, and salol. The salol principle can be applied to esters in which only the alcohol or the acid is the toxic, active or corrosive portion this type is called a partial salol. Examples of partial sulols that contain an active acid arc ethyl salicylate and methyl salicylate. Examples of partial sulols that contain an active phenol are creosote carbonate, thymol carbonate, and guaiacol carbonate. Althtxigh many. salol-typc compounds have been prepared and used tu. some extent, none is presently... 

Partial Salols—are sueh eompounds wherein either the acid or the hydroxylic moiety is active pharmaeologically. 

What are Salol, Partial Salol and True Salol Give the structure, chemical name and uses of one typical examples from each type. 

The production of partially disordered solids by these techniques will generally result in properties intermediate between the pure crystalline and amorphous phases. Florence and Salole (1976) foun< that the generation of partial amorphous character in digoxin samples by milling resulted in 7-118% increases in the apparent solubility, depending on the type and comminution. 

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