Salol principle

Nencki introduced salol in 1886 and. so pre.sented to the science of therapy the "salol principle." In salol. two toxic sub.stances (phenol and salicylic acid) were combined into an e.ster that taken internally slowly hydroly/es in the intestine to give the antiseptic action of its components. This type of ester is referred to as a full. salol or true salol when toth components of the ester are active compounds. Examples are guaiacol benzoate. /3-naphthol benzoate, and salol. The salol principle can be applied to esters in which only the alcohol or the acid is the toxic, active or corrosive portion this type is called a partial salol. Examples of partial sulols that contain an active acid arc ethyl salicylate and methyl salicylate. Examples of partial sulols that contain an active phenol are creosote carbonate, thymol carbonate, and guaiacol carbonate. Althtxigh many. salol-typc compounds have been prepared and used tu. some extent, none is presently... 

Necki (1886) first conceived the interesting salol principle , whereby he exploited the beneficial properties of phenols and carboxylic acids possessing potent antibacterial characteristic features into the design of newer drug molecules with better and improved pharmacological activities by means of simple esterification. 

A few typical examples wherein the hyberdisation was accomplished commencing from two bioactive entities i.e., implementation of the full-salol principle occurred, as stated under ... 

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