Naphthalene, 1,2-dihydroxy-, effect

Considerations of this kind also provide an alternative explanation for a number of phenomena which for some time have been attributed to bond fixation (Mills-Nixon effect).11 Thus the fact that 2,7-dihydroxy-naphthalene couples only in the 1- or the 8-position has been taken as... 

The effectiveness of 2,6-naphthalene moiety in depressing melting temperature is also demonstrated by copolymers containing 2,6-dioxynaphthalene or 2,6-naphthoyl units. It was reported, e.g., the melting point of the polymer of terephthalic acid and 2,6-dihydroxynaphthalene was only 210 °C (Harris, 1981) that of the copolymer of 2 mol 4-hydroxybenzoic acid with 1 mol of 2,6-dihydroxy-naphthalene and 1 mol of terephthalic acid was 285 (Calundann, 1980) that of the copolymer of 1 mol hydroquinone, lmol of 2,6-naphthoic acid and 3 mol 4-hydroxybenzoic acid was 325 °C-340 °C and that of 1 mol 2,6-naphthoic acid, 1 mol 4,4 -dihydroxybiphenyl, 3mol 4-hydroxybenzoic acid was 385°C-390°C (Calundann, 1978). 

Various flavonoids and related compounds have been tested as inhibitors for cyclooxygenase and lipoxygenase. Some are more effective as lipoxygenase inhibitors, and some more effective as cyclooxygenase inhibitors. Thus, 3, 4 -dihydroxy-flavone and 1,5-dihydroxy-naphthalene are potent inhibitors of 12-HETE formation in rat lung and spleen homogenates. IC50 values are 3.3 X 10 M and 2 X 10 M, respectively [394],... 

It has been found by experiment that substances of the type RX, containing two different haptenic groups, do not form precipitates with either anti-R serum or anti-X serum Alone, but do form precipitates with a mixture of the two specific antisera. This provides proof of the effective bivalence of the dihaptenic precipitating antigen, and thus furnishes further evidence for e framework theory of antigen-antibody precipitation. In these experiments tiie anti-R serum and anti-X serum were made by injecting rabbits with sheep serum coupled with diazotized p-arsanilic add and diazotized p-aminobenzoic acid, respectively, and the RX substances used were l-amino-2-/>-(p-azophenylazo)-phenylarsonic acid-3,6-disul-fonic add 7-p-(p-azophenylazo)-benzoic acid-8-hy-droxynaphthalene and l,8-dihydroxy-2-/>-azo-phenylarsonic acid-3,6-disulfonic acid-7-p-(p-azo-phenylazo)-benzoic acid-naphthalene. 

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