Nanophase ceramics functions

Enhanced osteoblast and osteoclast functions on nanophase ceramics due to increased surface wettability. Compared to conventional ceramics, nanophase ceramics exhibit enhanced surface wettability [evidenced, for example, by aqueous contact angles three times smaller... 

Due to their ability to selectively promote both osteoblast and osteoclast function, nanophase ceramics provide a preferable alternative to conventional orthopedic and dental implants that fail to integrate with surrounding bone it is undoubtedly highly desirable to minimize, if not avoid, clinical complications that necessitate removal of failed implants as a result of poor surface properties that lead to insufficient osseointegration. These results provide evidence that nanoceramics may be synthesized to match surface properties of bone and, thus, demonstrate strong promise and potential for their use in orthopedic and dental applications. 

Webster, T. J., Ergun, C., Doremus, R. H., Siegel, R. W., and Bizios, R., Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials 21,1803-1810 (2000b). 

Nanoparticles, see Supported nanoparticles Nanophase ceramics adhesion of osteoblasts to ceramic surfaces, 152-153 bending properties, 158 enhancing osteoblast and osteoclast functions, 153-155... 

Webster TJ, Ergun C, Doremus RH, Siegel RW, Bizios R. Enhanced osteoblast functions on nanophase ceramics. J Biomed Mater Res 2000 51 475-9. 

An innovative strategy to enhanee the mechanieal properties of biodegradable polymers is the ineorporation of nanomaterials as fillers within polymer matrices. With the appropriate modifications to facilitate dispersion into polymers and to enhance interactions with the snrronnding matrix, nanocomposites have demonstrated improved mechanical properties compared with unfilled polymers or polymers loaded with larger, micrometersized particles. A few studies have also shown enhanced cell function when bone cells are cultured on nanophase ceramic materials. 

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