Nanoparticles loaded with ampicillin

Fattale et al. [3.46] compared negatively charged liposomes with nanoparticles from poly- (isohexyl-cyanoacrylate), which of both were loaded with ampicillin. Both carriers were of approximately the same size 200 nm but the nanoparticles could be loaded with approx, twenty times more ampicilin. After freeze drying and storage at-4 °C, no ampicillin leaked from the nanoparticles, while it migrated quickly from the liposomes. 

Balland, O. Pinto-Alphandary, H. Pecquet, S. Andremont, A. Couvreur, P. The uptake of ampicillin-loaded nanoparticles by murine macrophages infected with salmonella typhimurium. J. Antimicrob. Chemother. 1994, 33, 509-522. 

Pinto-Alphandary, H. Balland, O. Laurent, M. Andremont, A. Puisieux, F. Couvreur, P. Intracellular visualization of ampicillin-loaded nanoparticles in peritoneal macrophages infected in vitro with salmonella typhimurium. Pharm. Res. 1994, 11, 38 6. 

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