Nanoparticle dissolution rate

V Mer-insoluble drugs can be formulated as nanoparticles with high surface area and enhanced dissolution rates accompanied with reduced drug particles. Administering a compound as small particles... 

Hu, J. Johnston, K.P. Williams, R.O. 3rd Nanoparticle engineering processes for enhancing the dissolution rates of poorly water soluble drugs. Drug Dev. Ind. Pharm. 2004, 30 (3), 233-245. 

The dissolution rate and stability ofNMs over time is another crucial issue. Kittler et al. [32] have shown that the release of silver ions from a dispersion of silver nanoparticles in water, and consequently the toxicity towards human mesenchymal stem cells, increases significantly with time. In addition, the temperature and the nature of the biological medium (e.g., the presence of salts or biomolecules) are important factors influencing the dissolution of metal nanomaterials. Unfortunately, measurement of the dissolution... 

Should dissolution rate-enhancing principles be applied in the formulation development (e.g., wetting agents, micronisation, solubilising agents, solid solutions, emulsions and nanoparticles) ... 

In recent years, there has been increased interest in the application of nanoparticles for poorly water soluble compounds due to the enhancement of dissolution rates and bioavailability [70, 71]. Nano-particles can be used for oral, injectable. 

The main conclusion of Paciejewska s thesis is the necessity to consider the specific kinetics of interfacial phenomena when evaluating the stability of colloidal suspensions. This applies not only to binary, but to all kinds of colloidal suspensions. A major factor is the dissolution of the dispersed phase(s)—in particular if the solubility and the intrinsic dissolution rate are relatively large. Its relevance is especially pronounced for a large total surface area, which depends on the particle concentration and the specific surface of the particles and which determines the amount of substance that can be dissolved in a given period of time. For many nanoparticle (x < 100 nm) systems (e.g. additives for paints and coatings), it will not be permissible to ignore the influence of dissolution on the interfacial properties and even on suspension stability—independent from the Gibbs-Thomson effect, which becomes relevant at particle sizes below 10 nm (cf. Sect. 3.1.4). 

Cheow WS, Hadinoto K (2012) Self-assembled amorphous drug-polyelectrolyte nanoparticle complex with enhanced dissolution rate and saturation solubility. J Colloid Interface Sci 367 518-526... 

Li X, Xie QR, Zhang J, Xia W, Gu H (2011) The packaging of siRNA within the mesoporous structure of silica nanoparticles. Biomaterials 32 9546-9556 Liao C-C, Jarowski Cl (1984) Dissolution rates of coiticoid solutions dispersed on silica. J Pharm... 

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