NANC neurotransmission

Zygmunt PM, Zygmunt PK, Hogestatt ED, Andersson KE. Effects of omega-conotoxin on adrenergic, cholinergic and NANC neurotransmission in the rabbit urethra and detrusor. Br J Pharmacol 1993 110(4) 1285-90. 

Inhibitory NANC responses are mediated by both VIP and NO.. NO. partially mediates the airway smooth muscle relaxant effects of VIP in the isolated perfused guinea-pig lung, as NOS inhibitors prevent relaxation induced by VIP but not that induced by isoproterenol (Lilly et al., 1993b). A significant and appropriately timed increase in the NO. content of lung perfusion fluid can be measured in response to VIP (Fig. 7.4). These data support the conclusion that interactions of VIP with NO. products mediate a substantial component of iNANC transmission. In human airways, NOS stimulated as a result of iNANC neurotransmission accounts for a substantial proportion of this relaxant response. Bel-visi and co-workers have shown that the a-chymotrypsin-resistant component of the human iNANC response can be abolished by treatment with NOS inhibitors (Belvisi et al., 1992). 

NANC non-adrenergic non-cholinergic (neurotransmission) that component of response not mediated by noradrenaline or acetylcholine. Possible mediators include purines, e.g. ATP, and peptides, e.g. substance P. nano 10 ... 

EPSCs, excitatory postsynaptic currents EPSP, excitatory postsynaptic potentials NANC, nonadrenergic-nonchohnergic neurotransmission. 

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