NADP: L-hexonate dehydrogenase

All the enzymes of the hexose monophosphate shunt have been found in the supernatant fraction of the cell. The enzymes of the glucuronic pathway, with the exception of NADP-L-hexonate dehydrogenase and aldonolactonase, which are found in the supernatant fraction of the cell, have a complex intracellular distribution. All the enzymes involved in glucuronic acid-1-phosphate synthesis and in the conversion of glucuronic phosphate or glucuronic acid to L-xylose or ascorbic acid are associated with the endoplasmic reticulum. The enzymes involved in the conversion of L-xylose to D-xylose are found in mitochondria. Thus, the complete glucuronic pathway involves three different cell fractions. 

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