HEXON

Historically, the Redox process was used to achieve the same purification as in the Purex process (97,129). The reagents were hexone (methyl isobutyl ketone) as the solvent, dichromate as an oxidant, and A1(N02)3 as the salting agent. The chief disadvantages of hexone are its flammability and its solubihty in water. However, because A1(N03)3 collects in the highly radioactive waste, thereby impeding the latter s further processing, the Redox process was abandoned in favor of the Purex process. 

Hexone, see Methyl isobutyl ketone sec-Hexyl acetate Hexylene glycol... 

Hexone (methyl isobutyl ketone) sec-Hexyl acetate Hydrazine Hydrogen chloride... 

Methyl ethyl ketone peroxide Methyl formate Methyl iodide Methyl isoamyl acetate Methyl isobutyl carbinol Methyl isobutyl ketone (hexone)... 

Methyl isobutyl ketone, see Hexone Methyl mercaptan CT... 

Chemical Designations - Syrwnyms Hexone Isobutyl methyl ketone Isopropylacetone 4-Methyl-2-pentanone MIBK MK Chemical Formula (CH3)2CHCH2COCH3... 

To the stirred solution of 5 parts of N-(4-piperidyl)propionanilide, 6.85 parts sodium carbonate, 0.05 part potassium iodide in 120 parts hexone is added portionwise a solution of 3.8 parts /3-phenylethyl chloride in 24 parts 4-methyl-2-penlanone. The mixture is stirred and refluxed for 27 hours. The reaction mixture is filtered while hot, and the filtrate is evaporated. The oily residue is dissolved in 160 parts diisopropyl ether and the solution is filtered several times until clear, then concentrated to a volume of about 70 parts. The residue is then cooled for about 2 hours at temperatures near 0°C to yield N-[1-((3-phenyl-ethyl)-4-piperidyl] propionanilide, melting at about 83° to 84°C as described in U.S. Patent 3,141,823. 

A mixture of 3.2 parts 4-chloro-p-fluoro-butyrophenone, 3.5 parts 1-oxo-4-phenyl-2,4,8-triazaspiro(4,5)decane, 2 parts Na COs hd 0.1 part Kl in 200 parts hexone is refluxed with stirring for 50 hours. The mixture is cooled to room temperature, 200 parts water are added and the layers are separated. The organic layer is dried over 10 parts MgSO, ... 

Fig. 8. Preparative isolation of hexon antigen of EDS-76 by hydrophobic-interaction chromatography on Butyl-PG column (2x5 cm) (A) application of the allantoic fluid diluted (1 5) by 50 mM potassium acetate, pH 4,130 ml (B)0.01 mol/1 potassium acetate, pH 5.5 (C) 0.01 mol/1 potassium bicarbonate pH 8.0, 10% isopropanol (D) 0.01 mol/1 potassium carbonate pH 9.6, 10% isopropanol. EDS-0 — components of alantoic fluid eluted with buffer A, EDS-1 — desorbed hexon fraction eluted with buffer C, EDS-2 — fraction desorbed with buffer D [56]...

Hemoglobin, immobilization 36 — 38 Heparin. 145, 170, 172 Hexon antigens 156, 157 HPAC 145... 

Methyl isobutyl carbinol Methyl isobut ketone, see Hexone err... 

An icosahedral virus particle composed of 252 capsomeres 240 being hexons and 12 being pentons... 

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