N- succinimid

Phenacyl-6-aminopenicillate HCI D-Phenylglycyl Chloride HCI 4-Hydro xy-1,5-naphthyridine-3-carboxylic acid-N-succinimide ester... 

I n the above procedure, the use of 4-hydroxy-1,5-naphthyridine-3-carbonyl chloride in place of 4-hydroxy-1,5-naphthyridine-3-carboxyllc acid N-succinimide ester can also afford the same objective compound as above. The use of sodium thio-n-propoxide in place of sodium thiophenoxide can also give the objective compound in the form of the sodium salt. 

All of the above dyes can be purchased in N-succinimide activated form and used for labeling of amino groups (see below). The choice of fluor-ophores are more limited for labeling of thiol groups with maleimide derivatives of dyes, and especially for full synthesis of oligos using dye-labeled phosphoramidites. 

Hydroxy-1,5-naphthyridlne-3-carboxylic acid-N-succinimide ester... 

C10H5CI2FN2O2, 4 -Fluoropyrrolnitrin, 33B, 118 CioH8BrN02, p-Bromophenyl-N-succinimide, 26, 720 CloH8BrN302, 1 P Nitrophenyl-3-methyl-4-bromopyrazole, 38B, 247 C10H9NO2, 3-Phenylpyrrolidine-2,5-dione, 39B, 161 C10H9N3O, 1-(2-Formamidophenyl)imidazole, 44B, 191 CioHioBrNO, 1 -(2-Bromophenyl)pyrrolidin-2-one, 43B,... 

RTCP involves a reversible chain transfer (RT) process with a catalyst (Scheme 4a) that improves the dispersity control, as well as the mentioned small contribution of DT (Scheme Id). The catalyst can be, e.g., Af-iodosuccinimide (NIS) (Scheme 4a) [31], and works as a deactivator. Polymer (which is originally supplied by the conventional radical initiator) reacts with NIS to produce N-succinimide radical (NS ). NS works as an activator of Polymer-I to generate Polymer and NIS again. This cycle allows for frequent reversible activation of Polymer-I. This process is a reversible chain transfer of NIS that catalytically activates Polymer-I. Therefore, the polymerization was termed reversible chain transfer catalyzed polymerization (RTCP). Regarding the components used, RTCP is similar to initiators for continuous activator regeneration (ICAR)-ATRP [65]. Both systems use a monomer, a dormant species (alkyl iodide or alkyl bromide), a conventional radical initiator, and a deactivator [NIS or copper (II)] to regenerate a highly reactive activator [NS or copper (I)]. 

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