N-Nonyl deoxynojirimycin

Gaucher disease is caused by a deficiency in lysosomal beta-glucosidase activity. Deoxynojirimycins are known inhibitors of several enzymes, which include beta-glucosidase. Several alkylated deoxynojirimycins were screened for correction of N370S Gaucher mutant lysosomal beta-glucosidase activity in an intact cell assay (10). A-(n-nonyl)deoxynojirimycin... 

In vitro, N-nonyl deoxynojirimycin (NN-DNJ 20) inhibits hepatitis B virus ability to construct its M envelope protein in human liver cells. Apparently, minor cellular carbohydrate processing disruption (6%)results in a greater than 99% reduction in the secretion of hepatitis B virus. In vivOy using the standard woodchuck model for HBV with the woodchuck hepatitis virus, treatment with NN-DNJ (20) induced a loss of viremia (70). Not unexpectedly after treatment ceased, viral titers returned to pretreatment levels. 

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