N-Formyl-methionyl-leucyl-phenylalanine

Stenson, W.F., Mehta, J. and Spilbeig, I. (1984). Sulfiasalazine inhibition of binding of N-formyl-methionyl-leucyl-phenylalanine (FMLP) to its receptor on human neutrophils. Biochem. Pharm. 33, 407-412. 

McCall, C. E., Bass, D. A., DeChatelet, L. R., Link, A. S. J., Mann, M. (1979). In vitro responses of human neutrophils to N-formyl-methionyl-leucyl-phenylalanine correlation with effects of acute bacterial infection. J. Infect. Dis. 140,277-86. 

Painter, R.G. and Aiken, M.L. (1995). Regulation of the N-formyl-methionyl-leucyl-phenylalanine receptor recycling by surface membrane neutral endopeptidase-mediated degradation of ligand./. Leukoc. Biol. 58, 468-476. 

N-Formyl-methionyl-leucyl-phenylalanine-induc-ed neutrophil activation (actin reorganisation and chemotaxis) was inhibited by the nitric oxide donor, 1,2,3,4-oxatriazolium,5-amino-3-(3,4-dichlo-rophenyl)-chloride (Ward et al. 2000). 

Von Ritter, C., Grisham, M.B. and Granger, D.N. (1989). Sulfasalazine metabolites and dapsone attenuate formyl-methionyl-leucyl-phenylalanine-induced mucosal injury in rat ileum. Gasteroenterolog 96, 811-816. 

Avdi, N.J., Winston, B.W., Russel, M., Young, S.K., Johnson, G.L. and Worthen, G.S. (1996). Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation, y. Biol. Chem. 271, 33598-33606. 

CLA(2-Methyl-6-phenyl-3,7-dihydroimidazo( 1,2-)pyrazin-3-one, Tokyo Kasei Kogyo Co., Ltd.) was used as a chemiluminescent reagent for superoxide anion. Flur-3-AM(l-[2-Amino-5-(2,7-dichloro-6-hydroxy-3-oxo-9-xanthenyl)phenoxy]-2-(2-amino-5-methylphenoxy)ethane-N,N,N, N -tetraacetic acid, Dojindo Molecular Technologies Inc.) was used as a fluorescent calcium indicator. f-MLP(N-formyl-methionyl-L-leucyl-L-phenylalanine, Sigma) was used as agonist. 

Lee TH, Horton CE, Kyan-Aung U, Haskard D, Crea AE, Spur BW (1989) Lipoxin A4 and lipoxin B4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B4 and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. CUn Sci (Lond) 77 195-203... 

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