N-Acetyl-3-

Acetamidothiazole and its 4-alkyl derivatives react with chloro-sulfonic acid. The structure of the resulting products was a subject of controversy (172. 393-397). N-acetyl-A -(2-thiazolyl)-sulfamoyl chlorides (189) first proposed were then shown to be 2-acetamido-5-chloro-sulfonylthiazoles (190) (Scheme 120) (367. 368. 398). the latter assignment is based on infrared (368) and chemical evidence (367). 

Amide resonance within the N acetyl group competes with delocalization of the nitro gen lone pair into the ring... 

After the N acetyl protecting group has served its purpose it may be removed by hydrolysis liberating the ammo group... 

Another structural variation is the replacement of a hydroxyl group m a carbohydrate by an ammo group to give an ammo sugar The most abundant ammo sugar is one of the oldest and most abundant organic compounds on earth N Acetyl d glucosamine is the... 

N -acetyl-L-omithiae) Baracolohactrum coliforme B. suhtilis Streptomjces virginae arg , uracil Arghydroxamate lys 11... 

L-lysine (N-acetyl-L-lysine) Brevibacterium ketoglutamicum Nocardia sp. hom 75... 

More recendy the cis and trans isomers of the mosquito repellent CIC-4, a mixture of citroneUa isomers, have been separated by preparative hplc and bioassayed for effectiveness (23). Chiral-phase capillary gas chromatography and mosquito repellent activity of some oxazoUdine derivatives of (+)-and ( —)-citroneUal have been studied to find stmcture—activity relationships (24). Several 2-aLkyl- -acetyloxahdines have been synthesized and tested against mosquitoes, with further efforts using nmr to determine the rotational isomers of the more active N-acetyl-2,2-dimethyloxazohdine (25). 

Aceto-2,6-xylidide, diethylamino-as local anaesthetic, 1, 179 N-Acetylation... 

Benz[e][ 1,2]azaborine, 1,2-dihydro-2-methyl-halogenation, 1, 656 Benz[6]- 1-azafulvenes dimerization, 4, 309 Benz[c]-2-azafulvenes dimerization, 4, 309 Benzazatropolone X-ray analysis, 7, 494 1 -Benzazepine, N-acetyl-6-hydroxy-bromination, 7, 528... 

H-Benzo[a]carbazole, 4,4a,5,l 1,1 la,l Ib-hexahydro-synthesis, 4, 283 Benzo[b]carbazole, N-acetyl-photochemical rearrangements, 4, 204 Benzo[/]chroman-4-one, 9-hydroxy-2,2-dimethyl-synthesis, 3, 851 Benzochromanones synthesis, 3, 850, 851, 855 Benzochromones synthesis, 3, 821 Benzocinnoline-N-imide ring expansion, 7, 255 Benzocinnolines synthesis, 2, 69, 75 UV, 2, 127 Benzocoumarins synthesis, 3, 810 Benzo[15]crown-5 potassium complex crystal stmcture, 7, 735 sodium complex crystal stmcture, 7, 735 Benzo[ 18]cr own-6 membrane transport and, 7, 756 Benzo[b]cyclohepta[d]furans synthesis, 4, 106 Benzocycloheptathi azoles synthesis, 5, 120... 

N-Acetyl-(R)-phanylalanlna (6). The rhodium catalyst was obtained by adding (-) dlop 5 (from diethyl tartrate) to a benzene solution of [RhCi(cyclooctene)2]2 under Ar, and stirring for tS mn A solution of the Rh catalyst (1 mM in EtOH PhH 4 1) was introduced under Hj to a solution of a-N acetylamino- phenytacrylic acid 4 (molar ratio Rh 4 1.540) The solvent was evaporated, the residue dissolved In 0 5 N NaOH, the catalyst was filtered and the solution acidified and concentrated to dryness to give 6 (81% ee) in 90 95% yield... 

AcOCgFs, Et3N, DMF, 80°, 12-60 h, 72-95% yield. This reagent reacts with amines (25°, no Et3N) selectively in the presence of alcohols to form N-acetyl derivatives in 80-90% yield. 

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