Myxine

The mechanism of reduction of an A-oxide, the antibiotic myxin, 6-methoxy-l-phenazinol 5,10-dioxide, has also been examined [19]. Below pH 3, the protonated species of myxin is reduced in a single four-electron step to 6-methoxy-l-phenazinol, whereas between pH 3 and 9, two two-electron steps are observed that are most likely due to the formation of an intermediate, which is in turn reduced to 6-methoxy-l-phenazinol. At pH values greater than 9, a single wave is observed, apparently due to the four-electron reduction of the anion to 6-methoxyphenazinol. The postulated mechanism is shown in Figure 26.3. 

Figure 26.3 Mechanism of reduction of the antibiotic myxin. [From Ref. 19.]...

Bellamy, D. and Chester Jones, I. (1961). Studies on Myxine glutinosa. I. The chemical composition of the tissues. Comparative Biochemistry and Physiology 3,175-183. 

Kuhn K, Stolte H, Reale E.The fine structure of the kidney of the hagfish (Myxine glutinosa L.) A thin section and freeze-fracture study. Cell Tissue Res 1975 164(2) 201-13. 

Increasing frequencies of liver tumors in wild populations of fish is documented during the past decades, especially in brown bullhead (Ictalurus nebulosus) from the Pox River, Illinois (12% tumor frequency), in Atlantic hagfish (Myxine glutinosa) from Swedish estuaries (6%), in English sole from the Duwamish... 

Haddock, Melanogrammus aeglifinus, 715 Hagfish, Atlantic, Myxine glutinosa, 663 Hake... 

Subramanian S, Ross NW, MacKinnon SL. Myxinidin, anovel antimicrobial peptide from the epidermal mucus of hagfish, Myxine glutinosa L. Marine Biotechnol 2009 ll(6) 748-57. 

Falkner S, Marklund S, Mattisson PE, Rappe C. Hepatomas and other neoplasms in the atlantic hagfish (Myxine glutinosa) a histopathologic and chemical study. Ann N Y Acad Sci. 1978 298 342-55. 

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