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Myoglobin model systems

The model system for these calculations is carboxy-myoglobin starting from the X-ray coordinates (19). The polar hydrogen parameter set PARAM19 (20) was used for all calculations. In this representation there are 1532 atoms. It is not expected that the results of this work would change substantially if a different protein or if a different parameter set were used. [Pg.133]

Hard, S. and Kanner, J. (1989). Haemoglobin and myoglobin as inhibitors of hydroxyl radical generation in a model system of iron redox cycle. Free Rad. Res. Commun, 6, 1-10. [Pg.122]

K for myoglobin (Parak et al., 1981). Thus, measurements of (x ) at temperatures below this value should show a much less steep temperature dependence than measurements above, if nonharmonic or collective motions (whose mean-square displacement is denoted (x )c) are a significant component of the total (x ). Figure 21 illustrates the expected behavior of (x )v, x, and their sum for a simple model system in which a small number of substates are separated by relatively large barriers. In practice, the relative contributions of simple harmonic vibrations and coUective modes will vary from residue to residue within a given protein. [Pg.347]

An iron porphyrin is the prosthetic group in the oxygen transport and storage proteins, hemoglobin and myoglobin. Consequently there has been much interest in porphyrin complexes, especially of first row transition metals, as model systems for oxygen transport and storage. Much interest has also been shown in metal porphyrins as models for oxidases, in particular cytochrome P-450. [Pg.325]

Love and Pearson (6) have described a model meat system in which bovine muscle was ground and extracted with distilled, deionized water at 4°C until it was devoid of color, indicating the removal of all meat pigments, i.e., myoglobin and hemoglobin. Other water-soluble components would also be partially or completely extracted by this procedure. The remaining extracted muscle was then used as a model system to which purified myoglobin, ferrous iron and ferric iron were added back to ascertain their role in WOF. [Pg.288]

The dioxygen-carrying proteins, hemoglobin and myoglobin, as well as the many synthetic model systems that have been developed recently,44 will not be considered here in this chapter since their chemistry is mainly that of iron in the + 2 oxidation state. The present chapter is therefore restricted to a brief description of the structure and reactivity of some cytochrome and peroxidase proteins. [Pg.263]

Table 4 Mossbauer parameters of high-valent intermediates of peroxidases, met-myoglobin treated with H2O2 and two tetramesitylporphyrin(TMP) model systems ... Table 4 Mossbauer parameters of high-valent intermediates of peroxidases, met-myoglobin treated with H2O2 and two tetramesitylporphyrin(TMP) model systems ...
The initial step (ultrafast CO loss within 50 fs) of the photodissociation process of CO-ligated iron porphyrin imidazole (Scheme 3), the model system for the CO-Ligated hemoglobin and myoglobin, has been investigated by means of TD-DFT. On the basis of the one-dimensional PEC... [Pg.3817]

Both types of 02-metal complexes are known to exist in vitro model systems (for ref. see Ref.197,197al). An unequivocal decision about the real structure of 02-hemo-globin and 02-myoglobin has not been reached because some studies favor the Pauling-structure199, 200 other data the Griffith-structure197,201 ... [Pg.79]


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