Myeloperoxidase lipid mediator

Kostyuk VA, Kraemer T, Sies H, Schewe T. Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids. FEES Lett 2003 537 146-150. 

Zhang R, Shen Z, Nauseef WM, Hazen SL. 2002b Defects in leukocyte-mediated initiation of lipid peroxidation in plasma as studied in myeloperoxidase-deficient subjects Systematic identification of multiple endogenous diffusible substrates for myeloperoxidase in plasma. Blood 99 1802-810. 

S. L. Hazen, R. Zhang, Z. Shen, W. Wu, E. A. Podrez, J. C. MacPherson, et al.. Formation of Nitric Oxide-Derived Oxidants by Myeloperoxidase in Monocytes Pathways for Monocyte-.Mediated Protein Nitration and Lipid Peroxidation in Vivo, Circ Res 85 (1999) 950-8. 

Hazen, S.L., Zhang, R., Shen, Z., Wu, W., Podrez, E.A., MacPherson, J.C., Schmitt, D., Mina, S.N., Mukhopad-hyay, C., Chen, Y., Cohen, P.A., Hoff, H.F., and Abu-Soud, H.M. (1999) Forrnatton of nittic oxide-derived oxidants by myeloperoxidase in monocytes pathways for monocyte-mediated protein nitration and lipid... 

Non-enzymatic oxidative modification of phospholipids in chronically inflamed tissue is mediated by free radicals which are produced by enzymes including NADPH oxidase and myeloperoxidase (Zhang et al. 2002). While ozone may play an additional role in lipid oxidation in the lung, singlet oxygen produced by ultraviolet (UV) light is the mechanism particularly relevant for skin and eye pathologies. 

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