Musk Tibetine

Hemimellitene. In addition to some specialized solvent appHcations, hemimellitene can be converted to musk Tibetine [145-39-17, 1-/gf/-butyl-3,4,5trimethyl-2,6-dinitrobenzene (14) via 5-/ l -butyl-l,2,3-trimethylbenzene [98-23-7] (13). 

Fig. 4. Example of thermal energy analyser (TEA) standard analysis using CPSIL-19 column type. EGDN, Ethylene glycol dinitrate FNT, 2-fluoro-5-nitrotoluene MT, musk tibetine NB, nitrobenzene NG, nitroglycerine PETN, pentaerythritol tetranitrate and RDX, cyclotrimethylene trinitramine TNT, trinitrotoluene. Reprinted with permission from Warren et al. [46], Copyright (1999) Forensic Science Society.

Musk Ketone and Musk Ambrette. Musk Ketone is considered to have the closest odour to that of natural musk, and Musk Ambrette, as its name implies, has an odour reminiscent of ambrette seeds. Other nitromusks, which were discovered later, include Musk Tibetine and Moskene. The structures of these, together with the synthetic routes to Musk Xylene and Musk Ketone, are shown in Figure 4.51. Both of these are prepared from m-xylene through initial f-butylation. Nitration of the z-butyldimethylbenze ne thus produced gives Musk Xylene, and acetylation followed by nitration gives Musk Ketone. The other nitromusks are prepared by similar combinations of classical aromatic reactions. 

Musk tibetine C18H18N2O4 266.29 Synthetic nitro musk compound Uses fragrance and fixative in after-shave lotions, perfumes, etc. C, F 1.0% pet. - X... 

Baur went on to synthesize even better nitromusks, notably Musk Xylene, Musk Ketone and Musk Ambrette. These and similar molecules e.g. Musk Moskene and Musk Tibetine) became widely used in the perfume industry. The famous French perfumer Ernest Beaux reportedly used over 10% nitromusks, especially Musk Ketone, in Chanel No. 5 (1921), which reports indicate is still used in No. 5 today (see p333). Musk Ambrette s additional floral note was used to advantage... 

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