Muscular dystrophy agent

Inositols, ie, hexaliydrobenzenehexols, are sugars that have received increasing study and are useful in the treatment of a wide variety of human disorders, including vascular disease, cancer, cirrhosis of the Hver, frostbite, and muscular dystrophy (269). Myoinositol esters prepared by reaction with lower fatty acid anhydrides are useful as Hver medicines and nonionic surfactants the aluminum and ammonium salts of inositol hexasulfate are useful anticancer agents (270). Tetraarjloxybenzoquinones are intermediates in the preparation of dioxazine dyes (266,271). The synthesis of hexakis(aryloxy)benzenes has also beenpubUshed (272). 

Duchenne muscular dystrophy yerapam may decrease neuromuscular transmission in patients with Duchenne muscular dystrophy and prolong recovery from the neuromuscular blocking agent vecuronium. Decrease in verapamil dosage may be necessary. 

A3. Askanas, W., Identification of the agent responsible for the abnormal immuno-electrophoretie pattern of serum in Duchenne s progressive muscular dystrophy. Life Sci. 6, 1767-1773 (1966). 

Real-time detection was also used for an isothermal amplification procedure termed nucleic acid sequence-based amplification, for the detection of artificial human papilloma virus sequences in SiHa cells. This method was not applied to real samples, but demonstrates the clinical applicability of additional microchip enzymatic amplification methods. Not all clinical microchip PCR amplifications looked for infectious agents, however. Cheng et al. showed a microchip PCR method for multiplex amplifications of dystrophin gene fragments for the detection of mutations associated with muscular dystrophy. 

As an agent essential to cellular respiration. Alphato-copherol appears to be necessary in cellular respiration, primarily in heart and skeletal muscle tissues. Thus, muscular dystrophy has been produced experimentally in various animals on E-deficient rations however, vitamin E supplements have not been effective in treating people with muscular dystrophy. 

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