Muscles, skeletal electrophysiology

Just a year after Stephenson s classical paper of 1956, J. del Castillo and B. Katz published an electrophysiological study of the interactions that occurred when pairs of agonists with related structures were applied simultaneously to the nicotinic receptors at the endplate region of skeletal muscle. Their findings could be best explained in terms of a model for receptor activation that has already been briefly introduced in Section 1.2.3 (see particularly Eq. (1.7)). In this scheme, the occupied receptor can isomerize between an active and an inactive state. This is very different from the classical model of Hill, Clark, and Gaddum in which no clear distinction was made between the occupation and activation of a receptor by an agonist. 

Lapie P, Goudet C, Nargeot J, Fontaine B, Lory P (1996) Electrophysiological properties of the hypokalaemic periodic paralysis mutation (R528H) of the skeletal muscle alpha Is subunit as expressed in mouse L cells. FEBS Lett 382 244-248. 

Britt, J.O., Jr., Martin, J.L., Okerberg, C.V., Dick, E.J., Jr., (2000). Histopathologic changes in the hrain, heart, and skeletal muscle of rhesus macaques, ten days after exposure to soman (an organophosphorus nerve agent). Comp. Med. 50 133-9. Carmeliet, E., Vereecke, J. (2002). Cardiac Cellular Electrophysiology. Kluwer Academic Publishers, Boston. 

Marwaha, J. (1980b). Electrophysiological studies of the action of ketamine in frog skeletal muscle. Neuropharmacology 19 765-72. 

Alsen, C., J.B. Harris, and I. Tesseraux Mechanical and Electrophysiological Effects of Sea Anemone (Anemonia sulcata) Toxins on Rat Innervated and Dener-vated Skeletal Muscle. Br. J. Pharmac. 74, 61 (1981). 

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