Muscle skeletal, micrograph

FIGURE 17.12 Electron micrograph of a skeletal muscle myofibril (in longitndinal section). The length of one sarcomere is indicated, as are the A and I bands, the H zone, the M disk, and the Z lines. Cross-sections from the H zone show a hexagonal array of thick filaments, whereas the I band cross-section shows a hexagonal array of thin filaments. (Photo courtesy of Hugh Huxley, Brandeis University)... 

FIGURE 5-31 Structure of skeletal muscle, (a) Muscle fibers consist of single, elongated, multinucleated cells that arise from the fusion of many precursor cells. Within the fibers are many myofibrils (only six are shown here for simplicity) surrounded by the membranous sarcoplasmic reticulum. The organization of thick and thin filaments in the myofibril gives it a striated appearance. When muscle contracts, the I bands narrow and the Z disks come closer together, as seen in electron micrographs of (b) relaxed and (c) contracted muscle. 

Figure 19-6 (A) The structure of a typical sarcomere of skeletal muscle. The longitudinal section depicted corresponds to that of the electron micrograph, Fig. 19-7A. The titin molecules in their probable positions are colored green. The heads of only a fraction of the myosin molecules are shown protruding toward the thin actin filaments with which they interact.

Electron micrograph of a longitudinal section of a skeletal muscle fiber showing a number of myofibrils. Muscle protein is an unusual example of a structural protein with enzymatic activity. (Courtesy of Dr. Hugh Huxley)... 

Figure 21.23. Glycogen-Engorged Lysosome. This electron micrograph shows skeletal muscle from an infant with type II glycogen-storage disease (Pompe disease). The lysosomes are filled with glycogen because of a deficiency in a-1,4-glucosidase, a hydrolytic enzyme confined to lysosomes. The amount of glycogen in the cytosol is normal. [From H.-G. Hers and F. Van Hoof, Eds. Lysosomes and Storage Diseases (Academic Press, 1973), p. 205.]...

Fig. 13. Electron micrograph of myofibrils of frog skeletal muscle treated with polyclonal antibodies against chicken breast muscle /3-connectin. Note that there are several symmetrical stripes in each half of the A bands. For further details, see Maruyama etal. (1985b).

Figure 54.14 Thick filament. (A) An electron micrograph of a reconstituted thick filament reveals the presence of myosin head domains at each end and a relatively narrow central region. A schematic view below shows how myosin molecules come together to form the thick filament. (B) A diagram showing the interaction of thick and thin filaments in skeletal-muscle contraction. [(A, top) Courtesy of Dr. Hugh Huxley.]...

Histologically, patients show the presence of rimmed vacuoles and inclusion bodies in the muscle fibers (see Plate 15.11). Electron micrographs of affected skeletal muscle demonstrate prominent 15-21-nm tubulofilamentous inclusions within myonuclei. Weihl et al. [9] identified large TAR... 

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