Muscle regeneration process

Skeletal muscle responds to injury by the activation of a regeneration process (Bischoff, 1979). As described in more detail below, muscle regeneration is a repeated embryonic development of the skeletal muscle only that in this case it starts from the dormant mononucleated satellite cells located between the basal lamina and cell membrane of the adult skeletal muscle fiber. The final outcome after the muscle damage therefore depends not only on the extent of the damage itself but also on the efficiency of the... 

The process of human muscle regeneration is just a repeated process of muscle embryonic development (Figure 45. lA). The earliest myogenic precursors in this development are mononuclear myoblasts. These still monunucleated but... 

III. THE EFFECTS OF DFP ON THE REGENERATION PROCESS IN THE HUMAN SKELETAL MUSCLE... 

No significant changes in the levels of any of the three AChE mRNA species could be observed at any of the developmental stages of human muscle after treatment with DFP, suggesting that OPs have no direct influence on AChE expression in hiunan muscle dming the regeneration process. 

Hence in vivo, terpolymer P4 could act by protecting the heparin binding growth factors involved in the natural process of muscle regeneration and therefore favour their actions. This family of polymers should offer a new pharmaceutical potential for treating muscle atrophy and destruction and is worth studying further. 

---