Multivalent display

Low-Molecular-Weight Multivalent Displays Can Cluster Proteins. 2501... 

In another example of liposome usage, a multivalent display of a C-3-modified sialoside on liposomes has been shown to inhibit influenza virus replication [124]. Hemagglutinin and sialidase are both involved in both glycoproteins, are involved in attachment and detachment of viral particles on the host cell through recognition of sialyl residues. In this case, the C-3-modified sialoside liposome seems to be such a successful inhibitor of viral replication because it successfully targets two different enz)mes that act on multivalent carbohydrate displays. 

Figure 31 Kiessling s disulfated Le constructs 63 and 64 elicited different physiological effects when appended on multivalent displays to afford 61 and 62.

Naturally occurring carbohydrate multivalent displays are widespread in nature and include mucins, pathogen, and mammalian cell surfaces. Lectins, carbohydrate-binding proteins, often present multiple repeat carbohydrate binding domains. The interaction of multivalent presentations can result in the formation of numerous simultaneous non-co-valent bonds that proceed to afford the observed high avidity of carbohydrates (153). 

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