Scanning multistage

Several MS acquisition and data processing strategies are used for detection and structure elucidation of metabolites. The common metabolite detection strategies are summarized in Section 9.2.1, which include full MS scan, constant neutral loss, parent ion scan, multiple reactions monitoring, and mass defect filtering. The structure elucidation strategies feature product ion scan, multistage scan, and accurate mass measurement, which are reviewed in Section 9.2.2. 

Like quadrupole mass filters, QIT mass spectrometers are compact, simple to operate, relatively inexpensive, and have high scan speed. Because of their small size and low pumping requirements, these instruments have gained wide acceptance for field applications. High efficiency and sensitivity are other hallmarks of ion-trap instruments. An ion trap is also a useful device to conduct multistage MS experiments (MS" with n = 12 has been envisioned) and gas-phase ion-molecule reactions. It can serve as an effective detector for high-resolution... 

Patten, H. V. Lai, S. C. Macpherson, J. V. Unwin, P. R., Active sites for outer-sphere, inner-sphere, and complex multistage electrochemical reactions at polycrystalline boron-doped diamond electrodes (pBDD) revealed with scanning electrochemical cell microscopy (SECCM). Analytical Chemistry 2012, 84, 5427-5432. 

Unlike QqQ, the 3D IT is characterized by high duty cycles because the time to fill an ion trap and generate a mass spectrum is short. Therefore, ion trap instruments can be also used for non-target analysis by virtue of their MS" capability that allows the sequential and multistage isolation, in the same space and as a function of time, of precursor ions, fragmentation, trapping, and mass scanning. 

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