Multiplexing technique advantage

The purpose of multiobject spectroscopy (MOS) is to obtain spectra of many objects within a wide field of view. Modem spectrographs have fields of 5-200 arcmin wifhin which several fens to hundreds of objects may be observed simultaneously. With microslit techniques, the multiplex advantage may be increased still further. The main technological options are (Fig. 13) ... 

As an alternative, extremely sensitive detection can be achieved with reporter antibody probes tagged with intensely SERS-active compounds or with enzymes that react with substrates to yield SERS-active products. These methods often involve sandwich immunoassay techniques, which increase the number of required steps but offer the advantages of excellent sensitivity and the potential for label multiplexing. For example, Nie and coworkers recently reported the simultaneous detection of two types of antigens in a... 

The chemical world is often divided into measurers and makers of molecules. This division has deep historic roots, but it artificially impedes taking advantage of both aspects of the chemical sciences. Of key importance to all forms of chemistry are instruments and techniques that allow examination, in space and in time, of the composition and characterization of a chemical system under study. To achieve this end in a practical manner, these instruments will need to multiplex several analytical methods. They will need to meet one or more of the requirements for characterization of the products of combinatorial chemical synthesis, correlation of molecular structure with dynamic processes, high-resolution definition of three-dimensional structures and the dynamics of then-formation, and remote detection and telemetry. 

The main advantages of the current YI sensor are that it is extremely sensitive, is a label-free technique, has multiplexing capabilities, and allows for a compact design. As such it is a good candidate for the development of a reliable handheld... 

About 10 years ago, the ion-imaging method was developed for the measurement of the velocity of a quantum-state-ionized photoproduct [15,23]. This technique relies on using a position-sensitive ion detector at the end of a TOF mass spectrometer to measure the recoil of photofragments from the centerline of the spectrometer. This technique has a large multiplex advantage over other approaches. 

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