Multiple sclerosis acute relapses

Miller, D.H., Thompson, A.J., Morrissey, S.P., MacManus, D.G., Moore, S.G., Kendall, B.E., Moseley, I.F. and McDonald, W.I. (1992). High dose steroids in acute relapses of multiple sclerosis MRI evidence for a possible mechanism of therapeutic effect. J. Neurol. Neurosurg. Psych. 55, 450-453. 

Bames D, Huglies RA, Monds RW, Wade-Jones O, Brown P, Britton T, Francis DP, Perkin GD, Rudge P, Swaslr M, Kadifi H, Fai mer S, Frankel J (1997) Randomized trial of oral and inti avenous metlrylprednisolone in acute relapses of multiple sclerosis. Lancet 349 902-906. 

Interferon beta-lb Betaseron (Berlex/Chiron/Novartis) Acute relapsing-remitting multiple sclerosis... 

Inolimomab Prevention ot graft rejection Keliximab Rheumatoid arthritis Muromonab Prevention ot acute renal allograft rejection Natalizumab Acute relapse in multiple sclerosis Crohn s disease... 

The effect of berbamine on experimental allergic encephalitis (EAG) was investigated in Lewis rats. Amelioration of the acute-phase of EAE was only minimal, but the incidence of relapsing EAE was reduced by 65% for berbamine at a non-toxic treatment dosage of 60 mg/kg via gavage on alternate days. These results suggest that berbamine, and perhaps other bisbenzylisoquinoline alkaloids, may have a potential role in the therapy of progressive multiple sclerosis [189]. 

In the CNS, the major demyelinating disorder is multiple sclerosis (MS). MS should be differentiated from other disorders in which the histologic appearance of the lesions and the relapsing and remitting clinical course are similar. Acute MS lesions, in addition to plentiful foamy macrophages with increased proteases, have perivascular FCA-positive lymphocytes, EMA-positive and... 

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