Multiple independently targeted

MIRV Multiple Independently Targetable Reentry Vehicle... 

By the late 1990s the industry began to question the wisdom of developing a new drug candidate with multiple therapeutic targets using sequential, independent clinical trials for each indication. With the... 

The objective function may take the form of the likelihood or posterior distribution functions [5]. It is pertinent to mention that maximization of the likelihood function in case of independent normally distributed errors leads to the sum-of-squares (SOS) of the residuals, such as given by equation (1). Another approach to fitting multiple training targets is to use multi-objective optimization, which is concerned with simultaneous optimization of a set of objectives. 

Model-predictive control (MPC) uses process models derived from past process behavior to predict future process behaviour. The predictions are used to control process imits dynamically at optimum steady-state targets. MPC applications may also include the use of predicted product properties (inferential analyzers) and certain process calculations. Model-predictive controllers almost always include multiple independent variables. 

The importance of this case is that OS-CFAR can be analytically analysed without any approximations. Furthermore the resulting scaling factor Tos is completely independent of p. Figure 14 shows the typical behaviour of OS-CFAR in clutter edge and multiple target situations. The threshold follows the clutter contour with a certain safety distance. In two target situations the threshold is more or less unchanged compared with a pure noise situation. 

The samples (minimum four batches) included in the study should cover the expected normal variation of the process (target 3 sigma). If the batches used do not represent the full and normal process variation, the calculations are based on a historical value for process variation. The same batches are analyzed by multiple analysts (minimum 2) in different laboratories (minimum 3) using their own instruments, reagents, and solvents. Each analyst performs the entire method as described. Every sample should be analyzed at least twice (with independent sample preparation) in the same run. The replicates should also be blinded and randomly tested. 

The isopeptide bond between Ub and other proteins can be hydrolyzed there are multiple, ATP-independent proteases (the yeast Saccharomyces cerevisiae has at least 20 of them) whose common property is the ability to recognize Ub moiety and cleave at the Ub-adduct junction. One cause of the striking multiplicity of these deubiquitylating enzymes (DUBs) (17) is the diversity of their targets, which include linear (DNA-encoded) Ub fusions, Ub adducts with small nucleophiles such as glutathione, and also free and substrate-linked multi-Ub chains. 

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