Multifunctional polymers enzyme-inhibiting

In a recent study, some authors proposed the employment of thiolated polymers obtained by the immobilization of thiol groups on well-established multifunctional polymers such as poly(acrylates) and chitosans as functional agents having mucoadhesive, penetration enhancement, and enzyme-inhibiting properties [94,95]. 

Multifunctional carrier matrices offer various advantages for oral drug delivery. Their application for oral drug delivery is described in Chapter 8. Generally, such carriers can be used either to protect the drug from enzymatic degradation via steric hindrance or to directly inhibit enzymes. Multifunctional polymers that can inhibit GI proteolytic enzymes per se are polyacrylates and modifications thereof as well as polymer-inhibitor... 

Additionally, polymers such as polycarbophil and some carbopols have been identified as multifunctional polymers due to their capacity to inhibit certain proteolytic enzymes and are discussed in Section 52.5.4. ... 

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