Multidose containers nasal

Aqueous nasal drops and nasal sprays are preserved when they are supplied in multidose containers. In order to get a low level of microbiological contamination at the start, the use of sterilised water or sterilised solutions of preservatives as primary materials is recommended. 

Nasal drug delivery devices can be divided into multidose and unit-dose/bi-dose systems. Multidose systems consist of a container mounted with a mechanical pump dispenser that is designed to deliver multiple doses from one container (Fig. 1). The various requirements of the customer and of the formulation are respected in the design and performance of the delivery systems. Unit-dose and bi-dose systems are becoming increasingly attractive to the pharmaceutical industry. In particular, therapies that require precise performance in their delivery system employ these single/ dual-use disposable systems. 

Nasal preparations are supplied in multidose or singledose containers, provided, if necessary, with a suitable administration device, which may be designed to avoid contamination. 

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