Multidomain peptide

Aulisa L, Dong H, Hartgerink ID (2009) Self-assembly of multidomain peptides sequence variation allows control over cross-linking and viscoelasticity. Biomacromolecules 10 2694-2698... 

Figure 14.9 (a) Primary sequence of a series of multidomain peptides and (b) proposed mol-... 

The Ca2+-dependent neutral proteases called calpains are found within the cells of higher animals. The 705-residue multidomain peptide chain of a chicken calpain contains a papain-like domain as well as a calmodulin-like domain.328 It presumably arose from fusion of the genes of these proteins. At least six calpains with similar properties are known.329 Some have a preference for myofibrillar proteins or neurofilaments.330 They presumably function in normal turnover of these proteins and may play a role in numerous calcium-activated cellular processes.331-3323... 

To form catalytically productive enzyme/substrate complexes, many peptide bond cis-trans isomerases essentially require the location of the reactive bond of the substrate in the context of secondary binding sites or a specific spatial organization of the polypeptide chain thus creating features of stereo- and regiospecifi-city [19,20]. As in the case of many endoproteases, PPIases can utilize an extended array of catalytic subsites to enhance catalytic efficiency and substrate specificity. These properties precondition peptide bond cis-trans isomerases toward a complex reaction pattern. Consequently, biochemical investigations have led to the elucidation of three distinct molecular mechanisms that might be operative either in isolation or collectively in the cellular action of both prototypical and multidomain peptide bond cis-trans isomerases ... 

Dakota E, Wang Y (2011) Injectable multidomain peptide nanofiber hydrogel as a delivery agent for stem cell secretome. Biomacromolecules 12 1651-1657... 

Fig. 1 Supramolecular systems described in this chapter. Top-. The extracellular matrix inspires most of the work and consists of fibers to resist tensile stresses such as collagens, fibers to resist compressive stresses such as the glycosaminoglycans, and soluble factors for cell signalling. Bottom Natural systems such as collagen, coiled-coil structures, p-sheet peptides such as peptide amphiphiles and multidomain peptides, hybrid systems such as streptavadin-biotin cross-linked microparticles, and synthetic systems such as the UPy-based hydrogelators...

Structure, Function, and Regulation of Genes Encoding Multidomain Peptide Synthetases... 

In this chapter, we summarize the research on the enzymology of bioactive peptides structures and regulation of multidomain peptide synthetase genes are treated separately by Zuber and Marahiel (3). 

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