Multicomponent systems, solid surface polymer

The limit layer of the polymer, founded in intimate contact with the solid body surface accomplishes an interaction of adhesive origin, being constituted from several monolayers. It is important that not the individual macromolecules are adsorbed on surface, but - due to their associative character - the supramolecular formations materialise this effect. In the case of multicomponent systems, the adsorption is selective. For the systems without solvents, the con-form-ational spectrum of its macromolecules, within the transition layer is fundamentally modified. In this case, the profile of unitary distribution density of the chains within the adsorbed layer, below the point 0, is characterised by three domains the first one, near the interface, a rapid decay of density, according to the relation... 

The vehicle format we have used to produce aquasomes is the complex particulate multicomponent system. In general, complex particulate delivery systems are assemblies of simple polymers, complex lipid mixtures or ceramic materials that tend to measure individually between 30 and 500 nm in diameter. Being solid or glassy particles dispersed in an aqueous environment, they exhibit the physical properties of colloids their mechanism of action is controlled by their surface chemistry. They may deliver agents through a combination of specific targeting, molecular shielding, and slow release processes. 

Although a number of techniques have been devised to investigate the bulk domain structure of multicomponent polymer systems the detailed structure of the surface, i.e., the outermost few tens of angstroms, has been studied in much less detail. Since many of the important properties of a polymeric solid are dependent upon the surface structure and since the surface can differ considerably from the bulk a technique which can differentiate the surface from bulk properties is likely to be of considerable importance. 

---