Multi-sensors based on separation followed by integrated retention and detection

2 Multi-sensors based on separation followed by integrated retention and detection 

If the discriminating power of the separation system concerned is inadequate, chemical derivatization is one possible aid. Such is the case with a 

6 ION-SELECTIVE ELECTRODES (ISEs) AND ION-SENSITIVE FIELD-EFFECT TRANSISTORS (ISFETs) 

Even though the first electrochemical sensors based on potentiometric principles were developed early this century e.g. the glass electrode for pH 

In addition, use of two identical ISEs inserted in two different streams (one of fixed composition and the other receiving the injected sample) allows the reference electrode to be suppressed and endows the experimental set-up with greater robusmess. Finally, a separation unit coupled on-line with the system can be used to boost the selectivity and/or sensitivity and hence expand its scope of application. 

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