Multi-pulse slice selection

The slice selection procedure can be combined with a number of pulse sequences to spatially resolve NMR parameters or to contrast the profiles with a variety of filters. The most commonly used acquisition schemes implemented to sample echo train decays are the CPMG [(jt/2)0—(Jt)90] or a multi-solid echo sequence [(jt/ 2)0-(jt/2)9o]. In these instances, the complete echo train can be fitted to determine... 

A solid-state variant of the DANTE sequence (Fig. 5.3.15) is obtained by replacing the rf pulses and the free precession periods of the original sequence by line-narrowing multi-pulse sequences [Carl, Corl, Flepl, Hep2J. Such DANTE sequences can be used for selective excitation in solid-state spectroscopy (cf Fig. 7.2.8) and for slice selection in solid-state imaging (Fig. 5.3.16). 

Fig. 6.2.7 [Fral] Timing diagram for multi-slice imaging by the STEAM method. The third rf pulse is used for slice selection. It is repeated with different centre frequencies for acquisition of different slices.

A closely related technique can be used for multi-slice imaging (Fig. 6.2.7) [Fral]. The scheme of Fig. 6.2.5(c) is appended by further slice-selective 90° pulses with different centre frequencies, so that the magnetization of other slices is selected [Fral]. In this way, the otherwise necessary recycle delay can effectively be used for acquisition of additional slices. However, the contrast in each slice is affected by a different Ty weight, because is different for each slice. The technique can readily be adapted to line-scan imaging by applying successive slice-selective pulses in orthogonal gradients [Finl]. 

Efficient suppression of water signals is a side benefit of heteronuclear coherence transfer schemes. The heteronuclear multi-quantum coherence (HMQC) method (Fig. 7.3.4(b)) is a broad-band version of the HYCAT experiment of proton detected C imaging (cf. Fig. 7.2.30(a)) [Knii4]. The initial 90° pulse on is used for slice selection. For a heteronuclear AX system, single-quantum proton magnetization is transferred into heteronuclear zero- and double-quantum magnetization by a 90° C pulse after... 

Ramadan et alP have modified the sequence for localised COSY (L-COSY) by the use of a non-selective adiabatic half passage pulse and two pairs of adiabatic full passage inversion pulses for excitation and spatial refocusing along two orientations. The new sequence, called AL-COSY, has improved slice selection and chemical shift artefacts. Andronesi et al have performed multi-voxel 2D COSY and 2D TOCSY experiments in vivo for the first time. Spectra were obtained from 2D COSY with an 8 x 8 matrix and 64 ty increments at 3 T in six healthy human volunteers and three patients with glioblastoma multiforme spectra from 2D TOCSY were obtained at... 

Fig. 5.3.13 Hadamard encoding and decoding for simultaneous four-slice imaging. The encoding is based on four experiments, A-D. In each experiment, all four slices are excited by a multi-frequency selective pulse. Its phase composition is determined by the rows of the Hadamard matrix H2. The image response is the sum of responses for each individual, frequency selective part of the pulse. Thus, addition and subtraction of the responses to the four experiments separates the information for each slice. This operation is equivalent to Hadamard transformation of the set of image responses. Adapted from [Miil21 with permission from Wiley-Liss. Inc., a division of John-Wiley Sons, Inc.

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