Multi-product microbial cell factory

Optimization of a Multi-Product Microbial Cell Factory for Multiple Objectives - A Paradigm for Metabolic Pathway Recipe... 

Keywords Multi-product microbial cell factory. Mixed integer MOO (MIMOO), Metabolic pathway recipe, Pareto-optimal set. 

Optimization of a Multi-Product Microbial Cell Factory... 

Almost all works on optimization of a multi-product microbial cell factory focussed on a single objective (e.g., Schmid et al., 2004 Visser et al, 2004 Vital-Lopez et al, 2006). A common feature in these works is the pseudo-stationary assumption. Enzymatic reaction kinetics in a microbial cell factory are reversible and interdependent. In reality, the fluxes due to enzymatic reactions are never stationary. Given the limitations of a model, it is necessary to assume a pseudo-stationary state where some variables fluctuate about an averaged steady state within certain bounds. 

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